Companies by HQ LocationTech Companies and Startups Headquartered in Cambridge

Developer of the world's first cloud-native operating system, DBOS, and the DBOS Cloud transactional serverless computing platform. A simpler, more secure way to build fault-tolerant cloud applications. Based on 3 years of joint MIT-Stanford research, led

VULCAN ELEMENTS is changing the way to electrify aerospace, defense, and auto with decarbonization.

Eli is a platform that makes it easy for contractors, installers, and retailers to offer their customers incentives, rebates, and low-interest financing for consumer decarbonization projects. Think heat pump HVAC systems, EV chargers, heat pump hot water h

Pi Health is a provider of platforms to assist oncology-related clinical trials with identifying sites and helping sponsors manage sites

Sesame Sustainability is a SAAS company that offers industrial decarbonization platform for modeling, optimization, and analysis.

Wild Microbes is a next-generation microbial platform that makes everything from plastics to proteins. They develop new microbial strains, making scaling sustainable products faster and cheaper than ever.

Montai is harnessing nature's power through digital technology to treat and prevent chronic disease, hence improving health outcomes for as many people as possible. To address this crucial global concern, the business is pioneering cutting-edge technology

Istari makes digital engineering ecosystems a reality where all technologies are created digitally, free from real-world costs, schedules, and environmental impacts.

DEM Bio is pioneering the next generation of immunotherapeutics that unleash macrophages and immune phagocytes to eliminate tumors by targeting ‘Don’t eat me’ (DEM) and ‘Eat me’ (EM) signals on cancer cells and macrophages. Founded by Longwood Fund and is

Mantel is developing the first molten-salt based carbon capture technology. Our molten borates are designed to operate at the high temperatures found inside boilers, kilns, and furnaces – enabling highly efficient carbon capture that has not been possible

Datalign Advisory is a financial advisory firm that connects clients with a network of financial advisers.

Foundation Alloy leverage advanced materials technology to design novel alloys optimized for additive manufacturing.

FORAY bioscience is a biotechnology company that uses biomanufacturing techniques to produce wood products.

NuMind is a manufacturing company currently based in Cambridge, Massachusetts, United States. It has been founded in 2022 by Etienne Bernard and Samuel Bernard.

Cartwheel offers mental health support to students in order to help schools regain balance in the midst of the student mental health crisis. It works hand in hand to empower school staff, reduce family stress, and improve all students' mental health outcom

Digital twins are revolutionizing industries from aerospace to agriculture. Istari makes them simple and more secure, unlocking models and simulations for better products - better everything. A faster, cheaper, greener digital future awaits. With Istari,

We develop scalable quantum computers to tackle the world’s hardest computational challenges. Join us: https://jobs.polymer.co/atlantic-quantum.

Orbital Therapeutics aims to enhance global health by unleashing the full potential of RNA-based medicines to treat human disease in ways that were not previously possible.

Diagonal Therapeutics is a biotechnology startup that is pioneering a novel technique to finding and producing agonist antibodies. Diagonal Therapeutics platform combines novel computational and experimental methodologies to solve the traditional obstacles

Via Scientific to help scientists and bioinformaticians generate novel science that improves the world. It was founded in 2022.

Founded by Flagship Pioneering, Empress re-imagines the process of small molecule drug discovery. Our bioplatform harnesses the power of evolution, human molecular and genetic data, and artificial intelligence to focus on endogenous sources of inherently d

Omnipulse Biosciences offers single injection quantities suitable for clinical trials and commercial distribution to low-income countries

Sleepagotchi rewards users with a digital collectible for sticking to a consistent sleep schedule that they set for themselves in order to promote healthy sleeping habits.

ProFound Therapeutics is creating profound impacts on the understanding of biology and disease and the ability to create therapeutics.

StataDX is building the world's first point-of-care diagnostics platform for Neurology.

Nvelop Therapeutics is a biotechnology company that provides gene editing technology services for unmet major disease needs.

Tailbox is an MIT-backed startup bringing locations to life through generative AI powered stories. Our location-based social platform for explorers focuses on uncovering hidden gems and unique narratives in every city through immersive storytelling and per

Metaphore Biotechnologies use biomimicry and machine learning to unveil the revolutionary medicinal potential of functional molecular mimics. The MIMiCTM platform, developed by the business, is a computationally driven bio platform for developing novel the

Stack is a B2B SaaS computer vision information system company that aims to rethink the way warehouses are managed across the United States.

Thousands of collectors use evaluate.market to analyze NFTs. We are a remote, venture-backed company that is changing how people buy, sell, and analyze digital collectibles. Connect with us on Twitter and join our Discord to learn more.

Robigo is a biopesticide engineering the plant microbiome to reduce disease in crops.

Yard Stick measures soil carbon. Scientists and farmers alike know that climate-friendly agricultural practices have the potential to remove atmospheric CO2 at gigaton/year scale. When these practices are adopted, more carbon is stored in soils, improving

Tutor Intelligence is on a mission to bring robots to places they've never been before. We have made it cheap and easy for businesses of all sizes to hire robots as drop-in solutions for picking, placing, pal/depal, material handling, sorting, kitting, ins

Gesund.ai orchestrates the AI as-a-Medical Device lifecycle, providing privacy-centered access to diverse yet standardized medical data sources, and a unique analytical toolbox that fosters clinical validation, regulatory clearance and effective marketing.

Centessa Pharmaceuticals is a next-generation biopharmaceutical company that aims to reshape the traditional drug development process. The company applies an asset-centric R&D model at scale to advance a portfolio of highly validated programs led by indust

hC Bioscience is an innovator and pioneer of protein editing using context agnostic engineered tRNA. Their First in Class approach for protein editing advances beyond genome editing to direct modification of the proteome.

We are reinventing a future Internet. Private. Personal. Relevant. Powered by extraordinary technology. No cookies harmed in the process.

Atavistik Bio is a pre-clinical biotechnology company pioneering the identification of metabolite-protein interactions that have the potential to lead to the discovery and development of first-in-class drug candidates powered by distinct allosteric control

Themis AI, a spinoff from CSAIL MIT, was founded by MIT alumni and professors to empower the world to create, advance, and deploy trustworthy AI. Themis' technology enables trustworthy AI in high risk scenarios, rare events and anywhere imbalances and bias

AIRNA is a biotech company that is pioneering RNA editing therapies to improve the health of individuals suffering from both rare and common ailments.

ReNAgade Therapeutics focuses on the boundless potential of RNA therapeutics to treat disease. RNA delivery systems with a comprehensive RNA platform that allows for an all-RNA system for coding, editing, and gene insertion to produce new medications.

Fourth Power is an energy storage startup that uses thermal batteries. Through utility-scale thermal storage, the technique transforms renewable energy into an on-demand energy source.

Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders,

Garuda Therapeutics is developing off-the-shelf hematopoietic stem cell (HSC) therapies to treat a broad range of severe and life-threatening diseases.

Crossbow Therapeutics is a seed-stage, stealth-mode oncology startup company. The company develops antibody engineering for intracellular cancer targets.

Osmoses engages in decarbonizing gas separations to eliminate one gigaton of carbon emissions per year.

Fizz is building a debit card that helps college students in the U.S. started building out their credit without having to learn lessons about overzealous credit use the hard way.

K36 Therapeutics mission to translate epigenetic modulation of oncogenic pathways into first-in-class small molecule therapies.

Dianthus is the world’s only AI-first E-commerce company – built from the ground up to help small to medium E-commerce brands.

Abata Therapeutics, a company focused on translating the biology of regulatory T cells (Tregs) into transformational medicines for patients living with progressive multiple sclerosis (MS) and other severe autoimmune and inflammatory diseases.

Convergent Therapeutics is a clinical-stage biotechnology company exploring the full potential of dual-targeted combination strategies to treat cancer. Convergent has developed a therapeutic platform that is capable of targeting validated and novel cancer

FYTO is a technology company that develops systems that grow high quality crops using much less resources.

Kiwi biosciences is a biotech company that develops enzymes to make food for patients who suffer from Irritable Bowel Syndrome (IBS). The company was founded in 2020 and is based in Somerville, Massachusetts, United States.

Fluent Metal is developing production-grade liquid metal printing technology for more functional, sustainable, and economical metal parts. Our innovative approach allows for high scalability and process tunability, making high-quality metal AM more attaina

Novus is a communication technologies company whose products focus on productivity and creativity in content creation using the state-of-the-art approaches in Artificial Intelligence.

Hosta Labs automates the analysis of images and videos of interior structures for property insurance carriers to provide a full in-depth view of accurate replacement values and risks in the underwriting process and on raw material quantities and mitigation

NextPoint Therapeutics develops medications to expand the benefit of immunotherapies to cancer patients. The company offers immunotherapies for a validated checkpoint axis that is independent of PD-1/L1 and modulates both adaptive and innate immune systems

As schools and businesses return to work, they will be met with a number of new challenges: keeping students and employees safe, tracking outbreaks, and communicating to the public that they are taking responsible precautions. CoVerified provides a profe

Walden Biosciences is a biotechnology company focused on transforming the treatment of kidney disease. Founded by world-renowned experts in renal disease, Walden is applying its unique, systems-based approach to address the intersection between the patholo

Common Sense Machines is building artificial intelligence that learns to translate the world into a 3D simulation. Our platform, Real-to-Sim-to-Real, leverages the flexibility of human-like learning and the speed and precision of machines to enable one-sho

Faze Medicines is a biotechnology company harnessing the groundbreaking new science of biomolecular condensates to create medical breakthroughs.

AavantiBio is a biopharmaceutical company that provides gene transfer and gene editing therapies to treat genetic diseases.

TalkTo Inc. develops mobile applications. The Company offers an application that enables users to text directly to stores, restaurants, hotels, and other types of businesses. TalkTo serves the consumer discretionary sector.

Seismic Therapeutic is a biotechnology company integrating machine learning across the entire biologics discovery process to accelerate immunology drug development. Using our IMPACT™ platform, we are addressing the central challenges of biologics discovery

Be Bio is developing a proprietary class of engineered B cells as medicines that unleash the potential of cell therapies in applications beyond cytotoxicity.

Carbon Counts is creating a unique mobile game that will engage people to individually and collectively impact climate change

IoT-enabled analytics platform providing data-driven optimization of industrial liquid systems for manufacturing

Woho enables a new way to build, assembling a team, network, and system to construct from low to high-rise structures with unprecedented quality, precision, and efficiency. The company was founded in 2020 and based in Cambridge, Massachusetts.

Vigil Neuroscience is the world’s first microglia-focused therapeutics company. Our purpose is clear: to treat rare and common neurodegenerative diseases by restoring the vigilance of the microglia, the sentinel cells of the brain’s immune system. We are u

Verve's mission is to improve the limits of worker safety and well-being by pioneering the integration of robotics into functional apparel. They commercialize a lightweight, one-size fits most wearable that powers and protects workers all day long, so they

Parallel Bio created a human 'immune system in a dish' to discover drugs and immunotherapies more likely to work in patients.

Clasp Therapeutics offers to reach of immuno-oncology with novel precision medicines that enable the immune system to identify and specifically destroy hard-to-treat tumors bearing common driver mutations, regardless of tumor type.

Standard Biocarbon is produced by pyrolysis of biomass yielding a stable, porous material that is near pure carbon.

Akooda helps employees to navigate the digital, hybrid, and remote work world using AI and data science.

GentiBio is a biotherapeutics company developing engineered regulatory T cells (EngTregs) programmed to treat autoimmune allergic diseases. The early-stage biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology to develop e

Ceretype has pioneered the integration of fMRI into therapeutic applications in neuropsychiatry. Our uniquely scalable platform makes targeted biomarkers accessible, delivering actionable insights for our pharma/biotech partners. Our decades of expertise a

Tagomics transform disease diagnosis through comprehensive multitopic profiling.

SalioGen Therapeutics advances in curative genetic therapies using its Exact DNA Integration Technology (EDIT) platform, a mammal-derived genome engineering technology. It is focused on providing durable, safe, and affordable non-viral gene therapies to mo

Silvertree is on a mission to empower the world’s aging population. We are developing next-gen wearable technology that provides the right form of safety and connection for active older adults. Aging is a personal experience, yet aging with dignity and ind

Bicara Therapeutics, a wholly-owned subsidiary of Biocon based in Boston, U.S., is developing a pipeline of bifunctional antibodies that exploit the recent advances in immuno-oncology. Bicara enables access to the thriving innovation ecosystem in the U.S.

MOMA Therapeutics operates as a biotechnology company. MOMA Therapeutics discover the next generation of precision medicines by targeting the molecular machines that underlie human disease.

Thymmune Therapeutics is a preclinical biotechnology company based in Cambridge, MA applying proprietary insights in thymic engineering to develop and commercialize immune cell therapy products addressing significant opportunities with unmet clinical need

Einblick is a visual data computing platform that provides the fastest way for organizations to understand the past, predict the future, and make the best data-driven decisions for their business. Einblick customers include a large luxury German car brand,

Metrika is a monitoring and analytics platform that provides visibility and actionable insights into blockchain networks. The company was founded in 2019 and is headquartered in Cambridge, Massachusetts, United States.

Simnova Biotherapeutics is a biopharmaceutical company that focuses on the research and development of cell therapies for cancer treatment. The company's primary therapeutic focus is CAR-based cell therapy for patients with either hematologic malignancies

SYSO Technologies provides end-to-end renewable energy and storage management technology and services.

Magnet Biomedicine is a biotechnology research platform specializing in discovering true molecular glues. Magnet Biomedicine leverages its TrueGlue discovery platform, which utilizes the latest advancements in human biology and proteomics. This platform i

Myeloid Therapeutics is an immunology company focused on combining biology insights with cutting-edge technologies to harness myeloid cells and eradicate cancer and other diseases.

Akkio is a technology company that makes AI easy enough for anyone to use.

Salient Predictions uses ML & ocean data to provide long range weather forecast for use in diverse industries.

Lytica Therapeutics, Inc. is a biotechnology company focused on developing novel peptide therapeutics.

Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find t

Elemind is developing noninvasive neurotechnology to augment sleep, attention, and ultimately the human experience.

Watershed Informatics catalyzes discovery by democratizing access to bioinformatics tools for biologists. It enables life sciences organizations of any size to perform mission-critical bioinformatics analyses (such as bulk, single-cell, and spatial transcr

Safar Partners is a seed- to growth-stage venture fund.

Satellite Biosciences is leading the development and implementation of proprietary, off-the-shelf, implantable satellite organs as living therapeutic solutions that can transform the lives of millions of patients who suffer from serious diseases. Building

A cancer diagnosis is something no one wants to hear. Too often, cancer is detected late, once it has spread and treatment options are limited. But cancer can be more effectively treated with an intent to cure if caught in the earlier stages. At Thrive, an

Vedere is developing cutting-edge gene therapy products to restore functional vision to patients who have suffered vision loss from Inherited Retinal Degenerations (IRDs), as well as other causes of both genetic and non-genetic vision loss. While the vast

Vizgen is a privately held biotech company developing the next generation of spatially resolved, single-cell transcriptomics technology and toolbox. The company's patented MERFISH technology enables massively multiplexed, genome-scale nucleic acid imaging

Meter is a next-generation volumetric imaging technology in development.